胱天蛋白酶10

胱天蛋白酶10
識別號
別名	CASP10；, ALPS2, FLICE2, MCH4, Caspase 10, FLICE-2
外部ID	OMIM：601762 HomoloGene：50038 GeneCards：CASP10
相關疾病
	autoimmune lymphoproliferative syndrome type 2A、非霍奇金氏淋巴瘤
為以下藥物的標靶
	emricasan
基因位置（人類）
染色體	2號染色體
終止	201,229,428 bp
RNA表達模式
	; ; ; ;
	查閱更多表達數據
基因本體
分子功能	• death effector domain binding; • 肽酶活性; • 半胱氨酸型肽酶活性; • 血漿蛋白結合; • 水解酶活性; • 泛素蛋白連接酶結合; • cysteine-type endopeptidase activity involved in execution phase of apoptosis; • cysteine-type endopeptidase activity; • cysteine-type endopeptidase activity involved in apoptotic signaling pathway; • cysteine-type endopeptidase activity involved in apoptotic process;
細胞組分	• ripoptosome; • 細胞質基質; • CD95 death-inducing signaling complex; • 細胞質;
生物學過程	• positive regulation of I-kappaB kinase/NF-kappaB signaling; • apoptotic signaling pathway; • cell surface receptor signaling pathway; • 蛋白酶解; • 細胞凋亡; • regulation of apoptotic process; • execution phase of apoptosis; • activation of cysteine-type endopeptidase activity involved in apoptotic process;
	Sources:Amigo / QuickGO
直系同源
	843
	無數據
	ENSG00000003400
	無數據
	Q92851
	無數據
NM_001206524; NM_001206542; NM_001230; NM_001306083; NM_032974;
	NM_032976; NM_032977
	無數據
NP_001193453; NP_001193471; NP_001221; NP_001293012; NP_116756;
	NP_116758; NP_116759
	無數據
	維基數據
檢視/編輯人類

胱天蛋白酶10（英語：Caspase 10）是一種在人類中由CASP10基因編碼的酶。^[5]

該基因編碼的蛋白質是胱天蛋白酶家族的成員。胱天蛋白酶的連續活化在細胞凋亡的執行階段發揮着核心作用。胱天蛋白酶以無活性的酶原形式存在，在保守的天冬氨酸殘基處經歷蛋白水解加工，產生一大一小兩個亞基，然後二聚化形成活性酶。

胱天蛋白酶9裂解並活化胱天蛋白酶3和7，而該酶本身由胱天蛋白酶8加工。該基因的突變與II型自體免疫性淋巴細胞增生綜合症中出現的細胞凋亡缺陷相關。該基因有三種編碼不同異構體的選擇性剪接的轉錄變體。^[6]

相互作用

胱天蛋白酶10已被證明可以與以下物質相互作用：

參見

蛋白酶解圖譜（英語：The Proteolysis Map）

參考文獻

^ 與胱天蛋白酶10相關的疾病；在維基數據上查看/編輯參考.
^ 對Caspase 10起作用的藥物；在維基數據上查看/編輯參考.
^ ^3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000003400 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fernandes-Alnemri T, Armstrong RC, Krebs J, Srinivasula SM, Wang L, Bullrich F, Fritz LC, Trapani JA, Tomaselli KJ, Litwack G, Alnemri ES. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc Natl Acad Sci USA. October 1996, 93 (15): 7464–9. Bibcode:1996PNAS...93.7464F. PMC 38767  . PMID 8755496. doi:10.1073/pnas.93.15.7464  .
^ Entrez Gene: CASP10 caspase 10, apoptosis-related cysteine peptidase.
^ ^7.0 ^7.1 ^7.2 Vincenz, C; Dixit V M. Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling. J. Biol. Chem. (UNITED STATES). March 1997, 272 (10): 6578–83. ISSN 0021-9258. PMID 9045686. doi:10.1074/jbc.272.10.6578  .
^ ^8.0 ^8.1 Srinivasula SM, Ahmad M, Ottilie S, Bullrich F, Banks S, Wang Y, Fernandes-Alnemri T, Croce CM, Litwack G, Tomaselli KJ, Armstrong RC, Alnemri ES. FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis. J. Biol. Chem. (UNITED STATES). July 1997, 272 (30): 18542–5. ISSN 0021-9258. PMID 9228018. doi:10.1074/jbc.272.30.18542  .
^ Wang, J; Chun H J; Wong W; Spencer D M; Lenardo M J. Caspase-10 is an initiator caspase in death receptor signaling. Proc. Natl. Acad. Sci. U.S.A. (United States). November 2001, 98 (24): 13884–8. Bibcode:2001PNAS...9813884W. ISSN 0027-8424. PMC 61136  . PMID 11717445. doi:10.1073/pnas.241358198  .
^ Micheau, Olivier; Tschopp Jürg. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell (United States). July 2003, 114 (2): 181–90. ISSN 0092-8674. PMID 12887920. doi:10.1016/S0092-8674(03)00521-X  .
^ Goltsev, Y V; Kovalenko A V; Arnold E; Varfolomeev E E; Brodianskii V M; Wallach D. CASH, a novel caspase homologue with death effector domains. J. Biol. Chem. (UNITED STATES). August 1997, 272 (32): 19641–4. ISSN 0021-9258. PMID 9289491. doi:10.1074/jbc.272.32.19641  .
^ ^12.0 ^12.1 ^12.2 ^12.3 Gajate, Consuelo; Mollinedo Faustino. Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy. J. Biol. Chem. (United States). March 2005, 280 (12): 11641–7. ISSN 0021-9258. PMID 15659383. doi:10.1074/jbc.M411781200  .
^ Guo, Yin; Srinivasula Srinivasa M; Druilhe Anne; Fernandes-Alnemri Teresa; Alnemri Emad S. Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria. J. Biol. Chem. (United States). April 2002, 277 (16): 13430–7. ISSN 0021-9258. PMID 11832478. doi:10.1074/jbc.M108029200  .
^ Srinivasula, S M; Ahmad M; Fernandes-Alnemri T; Litwack G; Alnemri E S. Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES). December 1996, 93 (25): 14486–91. Bibcode:1996PNAS...9314486S. ISSN 0027-8424. PMC 26159  . PMID 8962078. doi:10.1073/pnas.93.25.14486  .
^ ^15.0 ^15.1 MacFarlane, M; Ahmad M; Srinivasula S M; Fernandes-Alnemri T; Cohen G M; Alnemri E S. Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J. Biol. Chem. (UNITED STATES). October 1997, 272 (41): 25417–20. ISSN 0021-9258. PMID 9325248. doi:10.1074/jbc.272.41.25417  .
^ Zheng, L; Schickling O; Peter M E; Lenardo M J. The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm. J. Biol. Chem. (United States). August 2001, 276 (34): 31945–52. ISSN 0021-9258. PMID 11395500. doi:10.1074/jbc.M102799200  .

拓展閱讀

Cohen GM. Caspases: the executioners of apoptosis. Biochem. J. 1997, 326 (Pt 1): 1–16. PMC 1218630  . PMID 9337844. doi:10.1042/bj3260001.
Clements GB, Klein G, Povey S. Production by EBV infection of an EBNA-positive subline from an EBNA-negative human lymphoma cell line without detectable EBV DNA. Int. J. Cancer. 1975, 16 (1): 125–33. PMID 170210. S2CID 30408863. doi:10.1002/ijc.2910160114.
Baumann K, de Rouffignac C, Roinel N, et al. Renal phosphate transport: inhomogeneity of local proximal transport rates and sodium dependence. Pflügers Arch. 1975, 356 (4): 287–98. PMID 1171445. S2CID 259484. doi:10.1007/BF00580003.
DuBridge RB, Tang P, Hsia HC, et al. Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system. Mol. Cell. Biol. 1987, 7 (1): 379–87. PMC 365079  . PMID 3031469. doi:10.1128/mcb.7.1.379.
Maruyama K, Sugano S. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Gene. 1994, 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
Fernandes-Alnemri T, Takahashi A, Armstrong R, et al. Mch3, a novel human apoptotic cysteine protease highly related to CPP32. Cancer Res. 1996, 55 (24): 6045–52. PMID 8521391.
Srinivasula SM, Ahmad M, Fernandes-Alnemri T, et al. Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc. Natl. Acad. Sci. U.S.A. 1997, 93 (25): 14486–91. Bibcode:1996PNAS...9314486S. PMC 26159  . PMID 8962078. doi:10.1073/pnas.93.25.14486  .
Vincenz C, Dixit VM. Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling. J. Biol. Chem. 1997, 272 (10): 6578–83. PMID 9045686. doi:10.1074/jbc.272.10.6578  .
Bourquin JP, Stagljar I, Meier P, et al. A serine/arginine-rich nuclear matrix cyclophilin interacts with the C-terminal domain of RNA polymerase II. Nucleic Acids Res. 1997, 25 (11): 2055–61. PMC 146702  . PMID 9153302. doi:10.1093/nar/25.11.2055.
Shu HB, Halpin DR, Goeddel DV. Casper is a FADD- and caspase-related inducer of apoptosis. Immunity. 1997, 6 (6): 751–63. PMID 9208847. doi:10.1016/S1074-7613(00)80450-1  .
Srinivasula SM, Ahmad M, Ottilie S, et al. FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis. J. Biol. Chem. 1997, 272 (30): 18542–5. PMID 9228018. doi:10.1074/jbc.272.30.18542  .
Goltsev YV, Kovalenko AV, Arnold E, et al. CASH, a novel caspase homologue with death effector domains. J. Biol. Chem. 1997, 272 (32): 19641–4. PMID 9289491. doi:10.1074/jbc.272.32.19641  .
MacFarlane M, Ahmad M, Srinivasula SM, et al. Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J. Biol. Chem. 1997, 272 (41): 25417–20. PMID 9325248. doi:10.1074/jbc.272.41.25417  .
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. Gene. 1997, 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
Hu S, Snipas SJ, Vincenz C, et al. Caspase-14 is a novel developmentally regulated protease. J. Biol. Chem. 1998, 273 (45): 29648–53. PMID 9792675. doi:10.1074/jbc.273.45.29648  .
Ng PW, Porter AG, Jänicke RU. Molecular cloning and characterization of two novel pro-apoptotic isoforms of caspase-10. J. Biol. Chem. 1999, 274 (15): 10301–8. PMID 10187817. doi:10.1074/jbc.274.15.10301  .
Wang J, Zheng L, Lobito A, et al. Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II. Cell. 1999, 98 (1): 47–58. PMID 10412980. doi:10.1016/S0092-8674(00)80605-4  .
Satoh S, Hijikata M, Handa H, Shimotohno K. Caspase-mediated cleavage of eukaryotic translation initiation factor subunit 2alpha. Biochem. J. 1999, 342 (Pt 1): 65–70. PMC 1220437  . PMID 10432301. doi:10.1042/0264-6021:3420065.

外部連結

GeneReviews/NCBI/NIH/UW 有關自體免疫性淋巴增殖綜合症的條目（頁面存檔備份，存於互聯網檔案館）
肽酶及其抑制劑的MEROPS在線數據庫：C14.011^{[失效連結]}

[1] 與胱天蛋白酶10相關的疾病；在維基數據上查看/編輯參考.

[2] 對Caspase 10起作用的藥物；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-3] 3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000003400 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8755496-5] Fernandes-Alnemri T, Armstrong RC, Krebs J, Srinivasula SM, Wang L, Bullrich F, Fritz LC, Trapani JA, Tomaselli KJ, Litwack G, Alnemri ES. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc Natl Acad Sci USA. October 1996, 93 (15): 7464–9. Bibcode:1996PNAS...93.7464F. PMC 38767  . PMID 8755496. doi:10.1073/pnas.93.15.7464  .

[entrez-6] Entrez Gene: CASP10 caspase 10, apoptosis-related cysteine peptidase.

[pmid9045686-7] 7.0 ^7.1 ^7.2 Vincenz, C; Dixit V M. Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling. J. Biol. Chem. (UNITED STATES). March 1997, 272 (10): 6578–83. ISSN 0021-9258. PMID 9045686. doi:10.1074/jbc.272.10.6578  .

[pmid9228018-8] 8.0 ^8.1 Srinivasula SM, Ahmad M, Ottilie S, Bullrich F, Banks S, Wang Y, Fernandes-Alnemri T, Croce CM, Litwack G, Tomaselli KJ, Armstrong RC, Alnemri ES. FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis. J. Biol. Chem. (UNITED STATES). July 1997, 272 (30): 18542–5. ISSN 0021-9258. PMID 9228018. doi:10.1074/jbc.272.30.18542  .

[pmid11717445-9] Wang, J; Chun H J; Wong W; Spencer D M; Lenardo M J. Caspase-10 is an initiator caspase in death receptor signaling. Proc. Natl. Acad. Sci. U.S.A. (United States). November 2001, 98 (24): 13884–8. Bibcode:2001PNAS...9813884W. ISSN 0027-8424. PMC 61136  . PMID 11717445. doi:10.1073/pnas.241358198  .

[pmid12887920-10] Micheau, Olivier; Tschopp Jürg. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell (United States). July 2003, 114 (2): 181–90. ISSN 0092-8674. PMID 12887920. doi:10.1016/S0092-8674(03)00521-X  .

[pmid9289491-11] Goltsev, Y V; Kovalenko A V; Arnold E; Varfolomeev E E; Brodianskii V M; Wallach D. CASH, a novel caspase homologue with death effector domains. J. Biol. Chem. (UNITED STATES). August 1997, 272 (32): 19641–4. ISSN 0021-9258. PMID 9289491. doi:10.1074/jbc.272.32.19641  .

[pmid15659383-12] 12.0 ^12.1 ^12.2 ^12.3 Gajate, Consuelo; Mollinedo Faustino. Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy. J. Biol. Chem. (United States). March 2005, 280 (12): 11641–7. ISSN 0021-9258. PMID 15659383. doi:10.1074/jbc.M411781200  .

[pmid11832478-13] Guo, Yin; Srinivasula Srinivasa M; Druilhe Anne; Fernandes-Alnemri Teresa; Alnemri Emad S. Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria. J. Biol. Chem. (United States). April 2002, 277 (16): 13430–7. ISSN 0021-9258. PMID 11832478. doi:10.1074/jbc.M108029200  .

[pmid8962078-14] Srinivasula, S M; Ahmad M; Fernandes-Alnemri T; Litwack G; Alnemri E S. Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES). December 1996, 93 (25): 14486–91. Bibcode:1996PNAS...9314486S. ISSN 0027-8424. PMC 26159  . PMID 8962078. doi:10.1073/pnas.93.25.14486  .

[pmid9325248-15] 15.0 ^15.1 MacFarlane, M; Ahmad M; Srinivasula S M; Fernandes-Alnemri T; Cohen G M; Alnemri E S. Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J. Biol. Chem. (UNITED STATES). October 1997, 272 (41): 25417–20. ISSN 0021-9258. PMID 9325248. doi:10.1074/jbc.272.41.25417  .

[pmid11395500-16] Zheng, L; Schickling O; Peter M E; Lenardo M J. The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm. J. Biol. Chem. (United States). August 2001, 276 (34): 31945–52. ISSN 0021-9258. PMID 11395500. doi:10.1074/jbc.M102799200  .

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