胱天蛋白酶10

位於2號人類染色體的基因

胱天蛋白酶10英语:Caspase 10)是一种在人类中由CASP10基因编码的[5]

胱天蛋白酶10
识别号
别名CASP10;, ALPS2, FLICE2, MCH4, Caspase 10, FLICE-2
外部IDOMIM601762 HomoloGene50038 GeneCardsCASP10
相关疾病
autoimmune lymphoproliferative syndrome type 2A、​非霍奇金氏淋巴瘤[1]
为以下药物的标靶
emricasan[2]
基因位置(人类
2号染色体
染色体2号染色体[3]
2号染色体
胱天蛋白酶10的基因位置
胱天蛋白酶10的基因位置
基因座2q33.1起始201,182,872 bp[3]
终止201,229,428 bp[3]
RNA表达模式




查阅更多表达数据
直系同源
物种人类小鼠
Entrez
Ensembl
UniProt
mRNA​序列

无数据

蛋白序列

无数据

基因位置​(UCSC)Chr 2: 201.18 – 201.23 Mb无数据
PubMed​查找[4]无数据
维基数据
查看/编辑人类

该基因编码的蛋白质是胱天蛋白酶家族的成员。胱天蛋白酶的连续激活在细胞凋亡的执行阶段发挥着核心作用。胱天蛋白酶以无活性的酶原形式存在,在保守的天冬氨酸残基处经历蛋白水解加工,产生一大一小两个亚基,然后二聚化形成活性酶。

胱天蛋白酶9裂解并激活胱天蛋白酶37,而该酶本身由胱天蛋白酶8加工。该基因的突变与II型自身免疫性淋巴细胞增生综合症中出现的细胞凋亡缺陷相关。该基因有三种编码不同异构体的选择性剪接的转录变体。[6]

相互作用

胱天蛋白酶10已被证明可以与以下物质相互作用

参见

参考文献

  1. ^ 與胱天蛋白酶10相關的疾病;在維基數據上查看/編輯參考. 
  2. ^ 對Caspase 10起作用的藥物;在維基數據上查看/編輯參考. 
  3. ^ 3.0 3.1 3.2 GRCh38: Ensembl release 89: ENSG00000003400 - Ensembl, May 2017
  4. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Fernandes-Alnemri T, Armstrong RC, Krebs J, Srinivasula SM, Wang L, Bullrich F, Fritz LC, Trapani JA, Tomaselli KJ, Litwack G, Alnemri ES. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc Natl Acad Sci USA. October 1996, 93 (15): 7464–9. Bibcode:1996PNAS...93.7464F. PMC 38767 . PMID 8755496. doi:10.1073/pnas.93.15.7464 . 
  6. ^ Entrez Gene: CASP10 caspase 10, apoptosis-related cysteine peptidase. 
  7. ^ 7.0 7.1 7.2 Vincenz, C; Dixit V M. Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling. J. Biol. Chem. (UNITED STATES). March 1997, 272 (10): 6578–83. ISSN 0021-9258. PMID 9045686. doi:10.1074/jbc.272.10.6578 . 
  8. ^ 8.0 8.1 Srinivasula SM, Ahmad M, Ottilie S, Bullrich F, Banks S, Wang Y, Fernandes-Alnemri T, Croce CM, Litwack G, Tomaselli KJ, Armstrong RC, Alnemri ES. FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis. J. Biol. Chem. (UNITED STATES). July 1997, 272 (30): 18542–5. ISSN 0021-9258. PMID 9228018. doi:10.1074/jbc.272.30.18542 . 
  9. ^ Wang, J; Chun H J; Wong W; Spencer D M; Lenardo M J. Caspase-10 is an initiator caspase in death receptor signaling. Proc. Natl. Acad. Sci. U.S.A. (United States). November 2001, 98 (24): 13884–8. Bibcode:2001PNAS...9813884W. ISSN 0027-8424. PMC 61136 . PMID 11717445. doi:10.1073/pnas.241358198 . 
  10. ^ Micheau, Olivier; Tschopp Jürg. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell (United States). July 2003, 114 (2): 181–90. ISSN 0092-8674. PMID 12887920. doi:10.1016/S0092-8674(03)00521-X . 
  11. ^ Goltsev, Y V; Kovalenko A V; Arnold E; Varfolomeev E E; Brodianskii V M; Wallach D. CASH, a novel caspase homologue with death effector domains. J. Biol. Chem. (UNITED STATES). August 1997, 272 (32): 19641–4. ISSN 0021-9258. PMID 9289491. doi:10.1074/jbc.272.32.19641 . 
  12. ^ 12.0 12.1 12.2 12.3 Gajate, Consuelo; Mollinedo Faustino. Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy. J. Biol. Chem. (United States). March 2005, 280 (12): 11641–7. ISSN 0021-9258. PMID 15659383. doi:10.1074/jbc.M411781200 . 
  13. ^ Guo, Yin; Srinivasula Srinivasa M; Druilhe Anne; Fernandes-Alnemri Teresa; Alnemri Emad S. Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria. J. Biol. Chem. (United States). April 2002, 277 (16): 13430–7. ISSN 0021-9258. PMID 11832478. doi:10.1074/jbc.M108029200 . 
  14. ^ Srinivasula, S M; Ahmad M; Fernandes-Alnemri T; Litwack G; Alnemri E S. Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES). December 1996, 93 (25): 14486–91. Bibcode:1996PNAS...9314486S. ISSN 0027-8424. PMC 26159 . PMID 8962078. doi:10.1073/pnas.93.25.14486 . 
  15. ^ 15.0 15.1 MacFarlane, M; Ahmad M; Srinivasula S M; Fernandes-Alnemri T; Cohen G M; Alnemri E S. Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J. Biol. Chem. (UNITED STATES). October 1997, 272 (41): 25417–20. ISSN 0021-9258. PMID 9325248. doi:10.1074/jbc.272.41.25417 . 
  16. ^ Zheng, L; Schickling O; Peter M E; Lenardo M J. The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm. J. Biol. Chem. (United States). August 2001, 276 (34): 31945–52. ISSN 0021-9258. PMID 11395500. doi:10.1074/jbc.M102799200 . 

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