滤过裂隙

滤过裂隙（filtration slits），即肾脏的组成肾元之肾小体内的鲍氏囊上之足细胞的"足突"叉合彼此形成"滤过裂隙"(或裂隙孔)、且裂隙极小(约为8 nm)，而带有负电荷、大分子以及带阴电性的分子会被阻挡在外。^[1] 滤过裂隙可对比于肾小球内皮细胞的膜孔(fenestra)，并由"裂隙隔膜"(slit diaphragm)跨越其上。

结构

一些研究表明，滤过裂隙的尺寸限制了大的分子(比如:血清白蛋白(直径约为15～30μm))、及细胞(比如:红血球(直径约6～8µm)和血小板(直径约2～4μm，厚0.2～1.5μm，平均体积7μm³))的通过。^[2] 运作"滤过裂隙"的正确功能需要的蛋白质包括肾病蛋白^[3]、NEPH1(KIRREL)、NEPH2(KIRREL3)^[4]、足蛋白，及CD2AP。^[5]

注释

^ Guyton, Arthur C.; Hall, John E. Textbook of Medical Physiology. Philadelphia: Elsevier Saunders. 2006: 316–317. ISBN 0-7216-0240-1.
^ George Jarad, Jeffrey H. Miner. Update on the glomerular filtration barrier. Current Opinion in Nephrology and Hypertension. 2009-05, 18 (3): 226–232 [2019-02-13]. ISSN 1473-6543. PMC 2895306  . PMID 19374010. （原始内容存档于2019-06-09）.
^ Wartiovaara, J.; Ofverstedt, L. G. R.; Khoshnoodi, J.; Zhang, J.; Mäkelä, E.; Sandin, S.; Ruotsalainen, V.; Cheng, R. H.; Jalanko, H.; Skoglund, U.; Tryggvason, K. (2004). "Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography". Journal of Clinical Investigation 114 (10): 1475–1483. doi:10.1172/JCI22562. PMC 525744. PMID 15545998
^ Neumann-Haefelin, E.; Kramer-Zucker, A.; Slanchev, K.; Hartleben, B.; Noutsou, F.; Martin, K.; Wanner, N.; Ritter, A.; Gödel, M.; Pagel, P.; Fu, X.; Müller, A.; Baumeister, R.; Walz, G.; Huber, T. B. (2010). "A model organism approach: Defining the role of Neph proteins as regulators of neuron and kidney morphogenesis". Human Molecular Genetics 19 (12): 2347–2359. doi:10.1093/hmg/ddq108. PMID 20233749
^ Fukasawa, H.; Bornheimer, S.; Kudlicka, K.; Farquhar, M. G. (2009). "Slit Diaphragms Contain Tight Junction Proteins". Journal of the American Society of Nephrology 20 (7): 1491–1503. doi:10.1681/ASN.2008101117. PMC 2709684. PMID 19478094

参阅

外部链接

Organology at UC Davis Urinary/mammal/vasc1/vasc3 - "Mammal, renal vasculature (EM, High)
MCG生理学 7/7ch04/7ch04p09
Histology image: 22402loa – 波士顿大学的组织学学习系统
Histology image: 22403loa – 波士顿大学的组织学学习系统

[guyton11-1] Guyton, Arthur C.; Hall, John E. Textbook of Medical Physiology. Philadelphia: Elsevier Saunders. 2006: 316–317. ISBN 0-7216-0240-1.

[2] George Jarad, Jeffrey H. Miner. Update on the glomerular filtration barrier. Current Opinion in Nephrology and Hypertension. 2009-05, 18 (3): 226–232 [2019-02-13]. ISSN 1473-6543. PMC 2895306  . PMID 19374010. （原始内容存档于2019-06-09）.

[3] Wartiovaara, J.; Ofverstedt, L. G. R.; Khoshnoodi, J.; Zhang, J.; Mäkelä, E.; Sandin, S.; Ruotsalainen, V.; Cheng, R. H.; Jalanko, H.; Skoglund, U.; Tryggvason, K. (2004). "Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography". Journal of Clinical Investigation 114 (10): 1475–1483. doi:10.1172/JCI22562. PMC 525744. PMID 15545998

[4] Neumann-Haefelin, E.; Kramer-Zucker, A.; Slanchev, K.; Hartleben, B.; Noutsou, F.; Martin, K.; Wanner, N.; Ritter, A.; Gödel, M.; Pagel, P.; Fu, X.; Müller, A.; Baumeister, R.; Walz, G.; Huber, T. B. (2010). "A model organism approach: Defining the role of Neph proteins as regulators of neuron and kidney morphogenesis". Human Molecular Genetics 19 (12): 2347–2359. doi:10.1093/hmg/ddq108. PMID 20233749

[5] Fukasawa, H.; Bornheimer, S.; Kudlicka, K.; Farquhar, M. G. (2009). "Slit Diaphragms Contain Tight Junction Proteins". Journal of the American Society of Nephrology 20 (7): 1491–1503. doi:10.1681/ASN.2008101117. PMC 2709684. PMID 19478094

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