全反式视黄醇脱氢酶 (NAD+)
全反式視黃醇脫氫酶 (NAD+)（英語：all-trans-retinol dehydrogenase (NAD+)，EC 1.1.1.105 （頁面存檔備份，存於網際網路檔案館）），是一種以NAD+或NADP+為受體、作用於供體CH-OH基團上的氧化還原酶。這種酶能催化以下酶促反應：
| 全反式視黃醇脫氫酶 (NAD+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| 識別碼 | |||||||||
| EC編號 | 1.1.1.105 | ||||||||
| CAS號 | 9033-53-8 | ||||||||
| 數據庫 | |||||||||
| IntEnz | IntEnz瀏覽 | ||||||||
| BRENDA | BRENDA入口 | ||||||||
| ExPASy | NiceZyme瀏覽 | ||||||||
| KEGG | KEGG入口 | ||||||||
| MetaCyc | 代謝路徑 | ||||||||
| PRIAM | 概述 | ||||||||
| PDB | RCSB PDB PDBj PDBe PDBsum | ||||||||
| 基因本體 | AmiGO / EGO | ||||||||
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全反式視黃醇脫氫酶 (NAD+)能以全反式視黃醇和全反式視黃醛為底物，且對NAD+/NADH輔因子有很強的特異性。這種酶既能識別處於游離態的底物也能識別與視黃醇結合蛋白相結合時的底物，但對結合狀態下的底物具有更高的親和性。[1]
參考文獻
- ^ Gough, W.H., VanOoteghem, S., Sint, T. and Kedishvili, N.Y. cDNA cloning and characterization of a new human microsomal NAD+-dependent dehydrogenase that oxidizes all-trans-retinol and 3α-hydroxysteroids.. J. Biol. Chem. 1998, 273: 19778–19785. PMID 9677409.
- Koen AL, Shaw CR. Retinol and alcohol dehydrogenases in retina and liver. Biochim. Biophys. Acta. 1966, 128: 48–54. PMID 5972368.
- Matsuzaka, Y., Okamoto, K., Tsuji, H., Mabuchi, T., Ozawa, A., Tamiya, G. and Inoko, H. Identification of the hRDH-E2 gene, a novel member of the SDR family, and its increased expression in psoriatic lesion.. Biochem. Biophys. Res. Commun. 2002, 297: 1171–1180. PMID 12372410.
- Lee, S.A., Belyaeva, O.V. and Kedishvili, N.Y. Biochemical characterization of human epidermal retinol dehydrogenase 2.. Chem. Biol. Interact. 2009, 178: 182–187. PMID 18926804.