全反式视黄醇脱氢酶 (NAD+)
全反式视黄醇脱氢酶 (NAD+)（英语：all-trans-retinol dehydrogenase (NAD+)，EC 1.1.1.105 （页面存档备份，存于互联网档案馆）），是一种以NAD+或NADP+为受体、作用于供体CH-OH基团上的氧化还原酶。这种酶能催化以下酶促反应：
| 全反式视黄醇脱氢酶 (NAD+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| 识别码 | |||||||||
| EC编号 | 1.1.1.105 | ||||||||
| CAS号 | 9033-53-8 | ||||||||
| 数据库 | |||||||||
| IntEnz | IntEnz浏览 | ||||||||
| BRENDA | BRENDA入口 | ||||||||
| ExPASy | NiceZyme浏览 | ||||||||
| KEGG | KEGG入口 | ||||||||
| MetaCyc | 代谢路径 | ||||||||
| PRIAM | 概述 | ||||||||
| PDB | RCSB PDB PDBj PDBe PDBsum | ||||||||
| 基因本体 | AmiGO / EGO | ||||||||
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全反式视黄醇脱氢酶 (NAD+)能以全反式视黄醇和全反式视黄醛为底物，且对NAD+/NADH辅因子有很强的特异性。这种酶既能识别处于游离态的底物也能识别与视黄醇结合蛋白相结合时的底物，但对结合状态下的底物具有更高的亲和性。[1]
参考文献
- ^ Gough, W.H., VanOoteghem, S., Sint, T. and Kedishvili, N.Y. cDNA cloning and characterization of a new human microsomal NAD+-dependent dehydrogenase that oxidizes all-trans-retinol and 3α-hydroxysteroids.. J. Biol. Chem. 1998, 273: 19778–19785. PMID 9677409.
- Koen AL, Shaw CR. Retinol and alcohol dehydrogenases in retina and liver. Biochim. Biophys. Acta. 1966, 128: 48–54. PMID 5972368.
- Matsuzaka, Y., Okamoto, K., Tsuji, H., Mabuchi, T., Ozawa, A., Tamiya, G. and Inoko, H. Identification of the hRDH-E2 gene, a novel member of the SDR family, and its increased expression in psoriatic lesion.. Biochem. Biophys. Res. Commun. 2002, 297: 1171–1180. PMID 12372410.
- Lee, S.A., Belyaeva, O.V. and Kedishvili, N.Y. Biochemical characterization of human epidermal retinol dehydrogenase 2.. Chem. Biol. Interact. 2009, 178: 182–187. PMID 18926804.